小林　千余子　講師
[自己紹介]

大阪教育大学、姫路工業大学（現兵庫県立大学）大学院を卒業後、ポスドクとして熊本大学（遺伝発生医学研究施設：発生医学研究センターの前身）、岡山大 学、カーネギー研究所（メリーランド州ボルチモア）、理化学研究所（神戸発生再生総合研究センター）、熊本大学(今度は発生医学研究所)をへて、奈良県立医科大学へと流れ着きました。熊本大学所属以外は、クラゲ、プラナリアなど、１０年近く下等無脊椎動物の再生現象を研究してきました。奈良県立医科大学で は、培養細胞を用いた細胞生物学的研究を取り込みながら、腔腸動物のパターニングでの細胞接着関連タンパク質の挙動を調べていきたいと思っています。腔腸 動物の細胞接着は誰も研究しておらず、さらに進化発生学や、発生生物学のモデルとしても研究可能な新領域です。興味のある方はぜひご一緒しましょう！ 
 [発表論文] [1]Yukako Uchiyama, Masaji Sakaguchi, Takeshi Terabayashi, Toshiaki Inenaga, Shuji Inoue, Chiyoko Kobayashi, Naoko Oshima, Hiroshi Kiyonari, Naomi Nakagata, Yuya Sato, Kiyotoshi Sekiguchi, Hiroaki Miki, Eiichi Araki, Sayoko Fujimura, Satomi S. Tanaka, and Ryuichi Nishinakamura. (2010) Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme. Proc. Natl. Acad. Sci. USA. 107:9240-9245 [2]Sayoko Fujimura, Qing Jiang , Chiyoko Kobayashi, Ryuichi Nishinakamura. (2010) Notch2 activation in the embryonic kidney depletes nephron progenitors. J. Am. Soc. Nephrol. 21:803-810 [3]Qing Jiang , Sayoko Fujimura, Chiyoko Kobayashi, Ryuichi Nishinakamura. (2010) Overexpression of Sall1 in vivo leads to reduced body weight without affecting kidney development. J. Biochem. 147: 445-450 [4]Bernhard Egger, Dirk Steinke, Hiroshi Tarui, Katrien De Mulder, Detlev Arendt, Gae¨tan Borgonie, Noriko Funayama, Robert Gschwentner, Volker Hartenstein, Bert Hobmayer, Matthew Hooge, Martina Hrouda, Sachiko Ishida, Chiyoko Kobayashi, Georg Kuales, Osamu Nishimura, Daniela Pfister, Reinhard Rieger, Willi Salvenmoser, Julian Smith, III, Ulrich Technau1, Seth Tyler, Kiyokazu Agata, Walter Salzburger1, Peter Ladurner1 (2009) To Be or Not to Be a Flatworm: The Acoel Controversy. PLoS ONE 4: 1-10 [5]Minoru Takasato, Chiyoko Kobayashi, Koji Okabayashi, Hiroshi Kiyonari, Naoko Oshima, Makoto Asashima, Ryuichi Nishinakamura (2008) Trb2, a mouse homolog of tribbles, is dispensable for kidney and mouse development. Biochem. Biophys. Res. Commun. 373: 648-652. [6]Chiyoko Kobayashi, Yumi Saito, Kazuya Ogawa, Kiyokazu Agata (2007) Wnt signaling is required for antero-posterior patterning of the planarian brain. Dev. Biol. 306: 714-724. [7]Masayo Sakaki-Yumoto*, Chiyoko Kobayashi*, Akira Sato, Sayoko Fujimura, Yuko Matsumoto, Minoru Takasato, Tatsuhiko Kodama, Hiroyuki Aburatani, Makoto Asashima, Nobuaki Yoshida, Ryuichi Nishinakamura* (2006) The murine homolog of SALL4 , a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates with Sall1 in anorectal, heart, brain and kidney development. Development 133:3005-3013 *equal contribution [8]Oleg Gusev, Hideki Ikeda, Tetsushi Okochi, Jae Min Lee, Masatsugu Hatakeyama, Chiyoko Kobayashi, Kiyokazu Agata, Hidenori Yamada, and Masayuki Saigusa (2004) Purification and cDNA cloning of the ovigerous-hair stripping substance (OHSS) contained in the hatch water of an estuarine crab Sesarma haematocheir. J. Exp. Biol. 207:621-32. [9]Serabi Hirasawa, Jeffrey A. Mendoza, David B. Jacoby, Chiyoko Kobayashi, Robert S. Fitzgerald, Brian Schofield, Srinivasan Chandrasegaran, Machiko Shirahata. (2003) Diverse cholinergic receptors in the cat carotid chemosensory unit. Adv. Exp. Med. Biol. 536: 313-319. [10] Jung Shan Hwang, Chiyoko Kobayashi, Kiyokazu Agata, Kauho Ikeo, Takashi Gojobori. (2003) Detection of apoptosis during planarian regeneration by the expression of apoptosis-related genes (and TUNEL assay). Gene 333:15-25. [11]Kiyokazu Agata, Toshimasa Tanaka, Chiyoko Kobayashi, Kentaro Kato, and Yumi Saitoh. (2003) Intercalary Regeneration in Planarians. Dev. Dyn. 226:308-316 [12]Francesc Cebria*, Chiyoko Kobayashi*, Yoshihiko Umesono, Masumi Nakazawa, Katsuhiko Mineta, Kazuho Ikeo, Tkashi Gojobori, Mari Itoh, Masanori Taira, Alejandro Sanchez Alvarado, Kiyokazu Agata. (2002) FGFR-related gene nou-darake restricts brain tissues to the head region of planarians. Nature 419:620-624 *equal contribution [13]Kazuya Ogawa, Chiyoko Kobayashi, Tetsutaro Hayashi, Hidefumi Orii, Kenji Watanabe, Kiyokazu Agata. (2002) Planarian fibroblast growth factor receptor homologues expressed in stem cells and cephalic ganglions. Dev. Growth Differ. 44:191-204 [14]Yoko Suda, Zakir M. Hossain, Chiyoko Kobayashi, Osamu Hatano, Michio Yoshida, Isao Matsuo, Shinichi Aizawa. (2001) Emx2 directs the development of diencephalon in cooperation with Otx2. Development 128:2433-2450 [15]Chiyoko Kobayashi, Taisaku Nogi, Kenji Watanabe, Kiyokazu Agata. (1999) Ectopic pharynxes arise by regional reorganization after anterior/posterior chimera in planarians. Mech. Dev. 89:25-34 [16]Chiyoko Kobayashi, Kenji Watanabe, Kiyokazu Agata. (1999) The process of pharynx regeneration in planarians. Dev. Biol. 211:27-38 [17]Chiyoko Kobayashi, Seitaro Kobayashi, Hidehumi Orii, Kenji Watanabe, Kiyokazu Agata. (1998) Identification of two distinct muscles in the planarian Dugesia japonica by their expression of myosin heavy chain genes. Zool. Sci. 15:861-869 [18]Kiyokazu Agata, Yukihiro Soejima, Kentaro Kato, Chiyoko Kobayashi, Yoshihiko Umesono, Kenji Watanabe. (1998) Structure of the planarian central nervous system (CNS) revealed by neuronal cell markers. Zool. Sci. 15:433-440 
 [総説] [1]小林千余子,　西中村隆一　(2008) Sall4ノックアウトマウス 分子細胞治療 7: 173-177 [2]小宮千佳, 小林千余子, 西中村隆一 (2005) Sall1タンパク(SALL1) 生体の科学 56:544-545 [3]小林千余子, 阿形清和 (2002) あの生物のRNAiプロトコルが知りたい！⑤　プラナリアのRNAiプロトコル細胞工学 21:1188-1193 [著書] [1]西中村隆一, 小林千余子. (2006) 再生医療のための発生生物学. 　10章 腎臓形成へのメカニズムと再生への挑戦　 浅島誠編著 コロナ社出版 　http://www.ncbi.nlm.nih.gov/pubmed?term=Kif26b,%20a%20kinesin%20family%20gene,%20regulates%20adhesion%20of%20the%20embryonic%20kidney%20mesenchymehttp://www.ncbi.nlm.nih.gov/pubmed?term=Kif26b,%20a%20kinesin%20family%20gene,%20regulates%20adhesion%20of%20the%20embryonic%20kidney%20mesenchymehttp://www.ncbi.nlm.nih.gov/pubmed/20299358http://www.ncbi.nlm.nih.gov/pubmed/20299358http://www.ncbi.nlm.nih.gov/pubmed?term=Overexpression%20of%20Sall1%20in%20vivo%20leads%20to%20reduced%20body%20weight%20without%20affecting%20kidney%20developmenthttp://www.ncbi.nlm.nih.gov/pubmed?term=Overexpression%20of%20Sall1%20in%20vivo%20leads%20to%20reduced%20body%20weight%20without%20affecting%20kidney%20developmenthttp://www.ncbi.nlm.nih.gov/pubmed?term=To%20Be%20or%20Not%20to%20Be%20a%20Flatworm:%20The%20Acoel%20Controversyhttp://www.ncbi.nlm.nih.gov/pubmed?term=To%20Be%20or%20Not%20to%20Be%20a%20Flatworm:%20The%20Acoel%20Controversyhttp://www.ncbi.nlm.nih.gov/pubmed?term=Trb2,%20a%20mouse%20homolog%20of%20tribbles,%20is%20dispensable%20for%20kidney%20and%20mouse%20development.%20Biochem.%20Biophyshttp://www.ncbi.nlm.nih.gov/pubmed?term=Wnt%20signaling%20is%20required%20for%20antero-posterior%20patterning%20of%20the%20planarian%20brainhttp://www.ncbi.nlm.nih.gov/pubmed?term=Wnt%20signaling%20is%20required%20for%20antero-posterior%20patterning%20of%20the%20planarian%20brainhttp://www.ncbi.nlm.nih.gov/pubmed?term=The%20murine%20homolog%20of%20SALL4%20,%20a%20causative%20gene%20in%20Okihiro%20syndrome,%20is%20essential%20for%20embryonic%20stem%20cell%20proliferation,%20and%20cooperates%20with%20Sall1%20in%20anorectal,%20heart,%20brain%20and%20kidney%20developmenthttp://www.ncbi.nlm.nih.gov/pubmed?term=The%20murine%20homolog%20of%20SALL4%20,%20a%20causative%20gene%20in%20Okihiro%20syndrome,%20is%20essential%20for%20embryonic%20stem%20cell%20proliferation,%20and%20cooperates%20with%20Sall1%20in%20anorectal,%20heart,%20brain%20and%20kidney%20developmenthttp://www.ncbi.nlm.nih.gov/pubmed?term=The%20murine%20homolog%20of%20SALL4%20,%20a%20causative%20gene%20in%20Okihiro%20syndrome,%20is%20essential%20for%20embryonic%20stem%20cell%20proliferation,%20and%20cooperates%20with%20Sall1%20in%20anorectal,%20heart,%20brain%20and%20kidney%20developmenthttp://www.ncbi.nlm.nih.gov/pubmed?term=Purification%20and%20cDNA%20cloning%20of%20the%20ovigerous-hair%20stripping%20substance%20(OHSS)%20contained%20in%20the%20hatch%20water%20of%20an%20estuarine%20crab%20Sesarma%20haematocheirhttp://www.ncbi.nlm.nih.gov/pubmed?term=Purification%20and%20cDNA%20cloning%20of%20the%20ovigerous-hair%20stripping%20substance%20(OHSS)%20contained%20in%20the%20hatch%20water%20of%20an%20estuarine%20crab%20Sesarma%20haematocheirhttp://www.ncbi.nlm.nih.gov/pubmed?term=Diverse%20cholinergic%20receptors%20in%20the%20cat%20carotid%20chemosensory%20unithttp://www.ncbi.nlm.nih.gov/pubmed?term=Diverse%20cholinergic%20receptors%20in%20the%20cat%20carotid%20chemosensory%20unithttp://www.ncbi.nlm.nih.gov/pubmed?term=Detection%20of%20apoptosis%20during%20planarian%20regeneration%20by%20the%20expression%20of%20apoptosis-related%20geneshttp://www.ncbi.nlm.nih.gov/pubmed?term=Detection%20of%20apoptosis%20during%20planarian%20regeneration%20by%20the%20expression%20of%20apoptosis-related%20geneshttp://www.ncbi.nlm.nih.gov/pubmed/12557208http://www.ncbi.nlm.nih.gov/pubmed/12557208http://www.ncbi.nlm.nih.gov/pubmed?term=FGFR-related%20gene%20nou-darake%20restricts%20brain%20tissues%20to%20the%20head%20region%20of%20planarianshttp://www.ncbi.nlm.nih.gov/pubmed?term=FGFR-related%20gene%20nou-darake%20restricts%20brain%20tissues%20to%20the%20head%20region%20of%20planarianshttp://www.ncbi.nlm.nih.gov/pubmed?term=Planarian%20fibroblast%20growth%20factor%20receptor%20homologues%20expressed%20in%20stem%20cells%20and%20cephalic%20ganglionshttp://www.ncbi.nlm.nih.gov/pubmed?term=Emx2%20directs%20the%20development%20of%20diencephalon%20in%20cooperation%20with%20Otx2http://www.ncbi.nlm.nih.gov/pubmed?term=Ectopic%20pharynxes%20arise%20by%20regional%20reorganization%20after%20anterior/posterior%20chimera%20in%20planarianshttp://www.ncbi.nlm.nih.gov/pubmed?term=Ectopic%20pharynxes%20arise%20by%20regional%20reorganization%20after%20anterior/posterior%20chimera%20in%20planarianshttp://www.ncbi.nlm.nih.gov/pubmed?term=The%20process%20of%20pharynx%20regeneration%20in%20planarians.%20Dev.%20Biol.%20211:27-38http://ci.nii.ac.jp/naid/110003369566http://ci.nii.ac.jp/naid/110003369566http://ci.nii.ac.jp/naid/110003323573shapeimage_3_link_0shapeimage_3_link_1shapeimage_3_link_2shapeimage_3_link_3shapeimage_3_link_4shapeimage_3_link_5shapeimage_3_link_6shapeimage_3_link_7shapeimage_3_link_8shapeimage_3_link_9shapeimage_3_link_10shapeimage_3_link_11shapeimage_3_link_12shapeimage_3_link_13shapeimage_3_link_14shapeimage_3_link_15shapeimage_3_link_16shapeimage_3_link_17shapeimage_3_link_18shapeimage_3_link_19shapeimage_3_link_20shapeimage_3_link_21shapeimage_3_link_22shapeimage_3_link_23shapeimage_3_link_24shapeima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