研究業績 ＜1999年以降＞ Hatakeyama J, Wakamatsu Y, Nagafuchi A, Kageyama R, Shigemoto R, Shimamura K. Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates. Development. 2014 Apr;141(8):1671-82. Mazahery AR, Suzuki K, Nagafuchi A, Miyajima M, Nakagata N, Orvis GD, Behringer RR, Yamada G. Functional analysis of ectodermal β-catenin during external genitalia formation. Congenit Anom (Kyoto). 2013 Mar;53(1):34-41. Kazutaka Ozono, Satoshi Komiya, Kenji Shimamura, Takaaki Ito and Akira Nagafuchi. Defining the roles of α-catenin in cell adhesion and cytoskeleton organization: Isolation of F9 cells completely lacking cadherin-catenin complex. Cell Struct. Func. 2011. 36 (1) : 131-143 2011 Shigenobu Yonemura, Yuko Wada, Toshiyuki Watanabe, Akira Nagafuchi, Mai Shibata. α-Catenin as a tension transducer that induces adherens junction development. Nat. Cell Biol. 12(6): 533-542, 2010 June Epub 2010 May 9 Inoue A, Nagafuchi A, Kikuchi A. Retinoic acid induces discrete Wnt-signaling-dependent differentiation in F9 cells. Biochem Biophys Res Commun. 390 (3): 564-569, 2009 Epub 2009 Oct 9. Kousaka K, Kiyonari H, Oshima N, Nagafuchi A, Shima Y, Chisaka O, Uemura T. Slingshot-3 dephosphorylates ADF/cofilin but is dispensable for mouse development. Genesis 46(5): 246-55, 2008 May; Masayuki Shimizu, Yoshitaka Fukunaga, Junichi Ikenouchi and Akira Nagafuchi. Defining the roles of beta-catenin and plakoglobin in LEF/TCF-dependent transcription using beta-catenin/plakoglobin-null F9 cells. Mol. Cell Biol. 28: 825-835, 2008 
 Junji Tominaga, Yoshitaka Fukunaga, Edgardo Abelardo and Akira Nagafuchi. Defining the function of beta-catenin tyrosine phosphorylation in cadherin-mediated cell-cell adhesion. Genes Cells, 13: 66-77, 2008

Huijie Liu, Satoshi Komiya, Masayuki Shimizu, Yoshitaka Fukunaga, and Akira Nagafuchi. Involvement of p120 carboxy-terminal domain in cadherin trafficking. Cell Struct Func., 32: 127-137, 2007

Yoshinori Doi, Shinji Tamura, Takao Nammo, Koji Fukui, Shinichi Kiso and Akira Nagafuchi. Development of complementary expression patterns of E- and N-cadherin in the mouse liver. Hepatology Research 37: 230-237, 2007

Komiya, S., Shimizu, M., Ikenouchi, J., Yonemura, S., Matsui, T., Fukunaga, Y., Liu, H., Endo, F., Tsukita, S., and Nagafuchi, A. Apical membrnae and junctional complex formation during simple epithelial cell differentiation of F9 cells. Genes to Cells. 10: 1065-1080, 2005 Fukunaga, Y., Liu, H., Shimizu, M., Komiya, S., Kawasuji, M., and Nagafuchi, A. Cell Struct Func . Defining the roles of beta-catenin and plakoglobin in cell-cell adhesion:
Isolation of catenin/plakoglobin-deficient F9 cells. Cell Struct Func . 30: 25-34,2005
 Yokoyama, S., K. Tachibana, H. Nakanishi, Y. Yamamoto, K. Irie, K. Mandai, A. Nagafuchi, M. Monden, Y. Takai. alpha-Catenin-independent Recruitment of ZO-1 to Nectin-based Cell-Cell Adhesion Sites through Afadin. Mol Biol Cell 12(6), 1595-609, 2001.
 Miyagishi, M., R. Fujii, M. Hatta, E. Yoshida, N. Araya, A. Nagafuchi, S. Ishihara, T. Nakajima, and A. Fukamizu.J. Regulation of Lef-mediated transcription and p53-dependent pathway by associating beta-catenin with CBP/p300. Biol. Chem. 275, 35170-35175, 2000. 
 Tachibana, K., H. Nakanishi, K. Mandai, K. Ozaki, W. Ikeda, Y. Yamamoto, A. Nagafuchi, S. Tsukita, and Y. Takai. Two cell adhesion molecules, nectin and cadherin, interact through their cytoplasmic domain-associated proteins. J.Cell Biol. 150,1161-1176, 2000.
 Takahashi, N., S. Ishihara, S. Takada, S. Tsukita, and A. Nagafuchi. Posttranscriptional regulation of alpha-catenin expression is required for wnt signaling in L cells. Biochem. Biophys. Res. Commun., 277, 691-698, 2000.
 Y. Imamura, M. Itoh, Y. Maeno, S. Tsukita, and A. Nagafuchi. Functional Domains of a-Catenin Required for the Strong State of Cadherin-based Cell Adhesion. J. Cell Biol. 144:1311-1322. (1999) Y. Maeno, S. Moroi, H. Nagashima, T. Noda, H. Shiozaki, M. Monden, S. Tsukita, and A. Nagafuchi. a-catenin-deficient F9 cells differentiate into signet ring cells. Am J Pathol. 154:1323-1328. (1999)
 T. Hiiragi, H. Sasaki, A. Nagafuchi, H. Sabe, S. C. Shen, M. Matsuki, K. Yamanishi, and S. Tsukita. Transglutaminase Type 1 and Its Cross-linking Activity Are Concentrated at Adherens Junctions in Simple Epithelial Cells. J Biol Chem. 274:34148-34154. (1999)
 K. Kubota, M. Furuse, H. Sasaki, N. Sonoda, K. Fujita, A. Nagafuchi, and S. Tsukita. Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions. Curr Biol. 9:1035-1038. (1999)
 T. Kitagawa, K. Matsumoto, A. Nagafuchi, S. Tsukita, and H. Suzuki. Co-expression of E-cadherin and a-catenin molecules in colorectal cancer. Surg Today. 29:511-518. (1999)
 H. Takeda, Y. Shimoyama, A. Nagafuchi, and S. Hirohashi. E-cadherin functions as a cis-dimer at the cell-cell adhesive interface in vivo. Nat Struct Biol. 6:310-312. (1999) http://www.ncbi.nlm.nih.gov/pubmed/24715457http://www.ncbi.nlm.nih.gov/pubmed/24715457http://livepage.apple.co.jp/http://livepage.apple.co.jp/http://www.ncbi.nlm.nih.gov/pubmed/21685705http://www.ncbi.nlm.nih.gov/pubmed/21685705http://www.ncbi.nlm.nih.gov/pubmed?term=alpha-Catenin%20as%20a%20tension%20transducer%20that%20induces%20adherens%20junction%20development.http://www.ncbi.nlm.nih.gov/pubmed?term=alpha-Catenin%20as%20a%20tension%20transducer%20that%20induces%20adherens%20junction%20development.http://www.ncbi.nlm.nih.gov/pubmed?term=Retinoic%20acid%20induces%20discrete%20Wnt-signaling-dependent%20differentiation%20in%20F9%20cells.http://www.ncbi.nlm.nih.gov/pubmed?term=Slingshot-3%20dephosphorylates%20ADF%2Fcofilin%20but%20is%20dispensable%20for%20mouse%20developmenthttp://www.ncbi.nlm.nih.gov/pubmed?term=Slingshot-3%20dephosphorylates%20ADF%2Fcofilin%20but%20is%20dispensable%20for%20mouse%20developmenthttp://www.ncbi.nlm.nih.gov/pubmed?term=Defining%20the%20roles%20of%20beta-catenin%20and%20plakoglobin%20in%20LEF/TCF-dependent%20transcription%20using%20beta-catenin/plakoglobin-null%20F9%20cells.%20Masayuki%20Shimizu,%20Yoshitaka%20Fukunaga,%20Junichi%20Ikenouchi%20and%20Akira%20Nagafuchhttp://www.ncbi.nlm.nih.gov/pubmed?term=Defining%20the%20roles%20of%20beta-catenin%20and%20plakoglobin%20in%20LEF/TCF-dependent%20transcription%20using%20beta-catenin/plakoglobin-null%20F9%20cells.%20Masayuki%20Shimizu,%20Yoshitaka%20Fukunaga,%20Junichi%20Ikenouchi%20and%20Akira%20Nagafuchhttp://www.ncbi.nlm.nih.gov/pubmed?term=Defining%20the%20function%20of%20beta-catenin%20tyrosine%20phosphorylation%20in%20cadherin-mediated%20cell-cell%20adhesion.%20Junji%20Tominaga,%20Yoshitaka%20Fukunaga,%20Edgardo%20Abelardo%20and%20Akira%20Nagafuchihttp://www.ncbi.nlm.nih.gov/pubmed?term=Defining%20the%20function%20of%20beta-catenin%20tyrosine%20phosphorylation%20in%20cadherin-mediated%20cell-cell%20adhesion.%20Junji%20Tominaga,%20Yoshitaka%20Fukunaga,%20Edgardo%20Abelardo%20and%20Akira%20Nagafuchihttp://www.ncbi.nlm.nih.gov/pubmed?term=Involvement%20of%20p120%20carboxy-terminal%20domain%20in%20cadherin%20trafficking.%20Huijie%20Liu,%20Satoshi%20Komiya,%20Masayuki%20Shimizu,%20Yoshitaka%20Fukunaga,%20and%20Akira%20Nagafuchihttp://www.ncbi.nlm.nih.gov/pubmed?term=Involvement%20of%20p120%20carboxy-terminal%20domain%20in%20cadherin%20trafficking.%20Huijie%20Liu,%20Satoshi%20Komiya,%20Masayuki%20Shimizu,%20Yoshitaka%20Fukunaga,%20and%20Akira%20Nagafuchihttp://www.ncbi.nlm.nih.gov/pubmed?term=Development%20of%20complementary%20expression%20patterns%20of%20E-%20and%20N-cadherin%20in%20the%20mouse%20liver.%20Yoshinori%20Doi,%20Shinji%20Tamura,%20Takao%20Nammo,%20Koji%20Fukui,%20Shinichi%20Kiso%20and%20Akira%20Nagafuchihttp://www.ncbi.nlm.nih.gov/pubmed?term=Development%20of%20complementary%20expression%20patterns%20of%20E-%20and%20N-cadherin%20in%20the%20mouse%20liver.%20Yoshinori%20Doi,%20Shinji%20Tamura,%20Takao%20Nammo,%20Koji%20Fukui,%20Shinichi%20Kiso%20and%20Akira%20Nagafuchihttp://www.ncbi.nlm.nih.gov/pubmed?term=Apical%20membrnae%20and%20junctional%20complex%20formation%20during%20simple%20epithelial%20cell%20differentiation%20of%20F9%20cells.%20Komiya,%20S.,%20Shimizu,%20M.,%20Ikenouchi,%20J.,%20Yonemura,%20S.,%20Matsui,%20T.,%20Fukunaga,%20Y.,%20Liu,%20H.,%20Endo,%20F.,%20Tsukita,%20S.,%20and%20Nagafuchihttp://www.ncbi.nlm.nih.gov/pubmed/16357441http://www.ncbi.nlm.nih.gov/pubmed/16357441http://www.ncbi.nlm.nih.gov/pubmed/16357441http://www.ncbi.nlm.nih.gov/pubmed?term=alpha-Catenin-independent%20Recruitment%20of%20ZO-1%20to%20Nectin-based%20Cell-Cell%20Adhesion%20Siteshttp://www.ncbi.nlm.nih.gov/pubmed?term=alpha-Catenin-independent%20Recruitment%20of%20ZO-1%20to%20Nectin-based%20Cell-Cell%20Adhesion%20Siteshttp://www.ncbi.nlm.nih.gov/pubmed?term=Regulation%20of%20Lef-mediated%20transcription%20and%20p53-dependent%20pathway%20by%20associating%20beta-cateninhttp://www.ncbi.nlm.nih.gov/pubmed/10974003http://www.ncbi.nlm.nih.gov/pubmed/10974003http://www.ncbi.nlm.nih.gov/pubmed/11062015http://www.ncbi.nlm.nih.gov/pubmed/11062015http://www.ncbi.nlm.nih.gov/pubmed/10087272http://www.ncbi.nlm.nih.gov/pubmed/10087272http://www.ncbi.nlm.nih.gov/pubmed/10329584http://www.ncbi.nlm.nih.gov/pubmed/10329584http://www.ncbi.nlm.nih.gov/pubmed/10567386http://www.ncbi.nlm.nih.gov/pubmed/10567386http://www.ncbi.nlm.nih.gov/pubmed/10508613http://www.ncbi.nlm.nih.gov/pubmed/10508613http://www.ncbi.nlm.nih.gov/pubmed/10385365http://www.ncbi.nlm.nih.gov/pubmed/10385365http://www.ncbi.nlm.nih.gov/pubmed/10201395http://www.ncbi.nlm.nih.gov/pubmed/10201395http://livepage.apple.co.jp/shapeimage_2_link_0shapeimage_2_link_1shapeimage_2_link_2shapeimage_2_link_3shapeimage_2_link_4shapeimage_2_link_5shapeimage_2_link_6shapeimage_2_link_7shapeimage_2_link_8shapeimage_2_link_9shapeimage_2_link_10shapeimage_2_link_11shapeimage_2_link_12shapeimage_2_link_13shapeimage_2_link_14shapeimage_2_link_15shapeimage_2_link_16shapeimage_2_link_17shapeimage_2_link_18sha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